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In contrast, we observed a higher arginine/proline media ratio (higher metabolite concentrations in arginine medium compared to proline medium) for succinate, cis -aconitate, citrate, norleucine, -alanine, creatinine, citramalate, lysine, aspartate, isoleucine, and 10,13-dimethyltetradecanoate in gdh3 / gdh3 mutants compared to wild type (Fig

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Immediate treatment post-debridement was crucial for optimal results

Abstract The pathophysiology of ALS involves many signs of a disruption in copper homeostasis, with both excess free levels and functional deficiency likely occurring simultaneously

Ethics declarations Competing interests The authors declare that they have no known competing financial interests or personal relationship that could have appeared to influence the work reported in this article