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Insulin facilitates the increased expression of -glutamylcysteine ligase (GCLc), the rate limiting enzyme in the initial step of glutathione assembly (Langston et al., 2008)

This is also the structure Novo Nordisk's own investigational semaglutide+cagrilintide combination used in REDEFINE 1 (Garvey et al., NEJM 2025) both components stepped in parallel through a 16-week ramp rather than introduced together at maintenance

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Conclusion: MT shows promise as an adjunctive intervention in managing acute cerebrovascular diseases, complementing established rehabilitation therapies