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You produce less ATP per unit of effort, which means reduced endurance, lower training capacity, and slower recovery

AOD-9604 and 5-Amino-1MQ are primarily researched in caloric deficit contexts where fat oxidation is the goal, but NAD+ restoration from 5-Amino-1MQ may support mitochondrial biogenesis and recovery during muscle-building phases

Overexpression of the leptin gene in adipocytes and increased circulating levels of leptin may also contribute to enhanced basal lipolysis in obesity (74)

Tomaszewski, M., et al

Trends in the surgical treatment of articular cartilage lesions in the United States: an analysis of a large private-payer database over a period of 8 years