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10.3390/molecules27082555 14 BellaviteP.A.-O.FazioS.A.-O.AffusoF

For in vivo metabolic analysis, mice were intraperitoneally injected with a 15 N-glutamine solution (40 mg/kg in PBS)

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CYP2E1 , Cytochrome P450 family 2 subfamily E member 1

Given that aging is associated with a decline of mitochondrial functions along with the development of aging-related diseases, and given that the tissue and circulating levels of MOTS-c fall with age, it is compelling to hypothesize that declining MDP levels are also related to age-related metabolic deterioration