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These reactions are generally transient and primarily occur in the initial phase

Agrawal, A

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Nonetheless, it should be used within a certain timeframe as recommended by the pharmacy (often 28 days after first puncture, per general guidelines for multi-dose vials, unless otherwise specified)

For other epigenetic mechanisms, including ATP-dependent chromatin remodeling, histone de/acetylation, neuron-restrictive silencing factor (NRSF/REST)-mediated gene regulation and non-coding RNA, we refer the reader to excellent reviews (Ballas et al., 2005