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In late-stage MASLD or end-stage heart failure, where mitochondria are severely compromised and NAD + depleted, SIRT1 activation may further aggravate oxidative injury by promoting mitochondrial fission and excessive autophagy, depleting cellular energy

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Glutathione-deficient mice have increased sensitivity to transplacental benzo[a]pyrene-induced premature ovarian failure and ovarian tumorigenesis.Cancer Res

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