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When COMT is slow, more 4-OHE2 remains available for oxidation to reactive quinones increasing demand on GSTM1/GSTT1 glutathione conjugation at exactly the point where their absence is most consequential

doi: 10.1016/S0736-0266(03)00110-4

Neutralizing free radicals: Glutathione helps neutralize unstable molecules called free radicals, reducing oxidative stress and preventing cellular damage (NIH)

Endocrine, 15 (1), 9195

Minor differences in the appearance of the lyophilized peptide (particularly color) between production lots are normal and generally reflect variations in copper content and freeze-drying conditions rather than differences in peptide identity or analytical purity