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It is recognized as the key to destroying fatty acid hydroperoxides ( Ferrozois, a new form of regulation of cell death, is primarily attributed to cellular lipid peroxidation (LPO) due to insufficient or absent GPX4 activity, ultimately causing cell death ( 2 O 2 ) to water (Figure 4)
Mobile phase B was 90% acetonitrile with 10 mM ammonium acetate, 0.1% ammonium hydroxide and 0.1% medronic acid
Drug Targets
Glutathione further plays an important role in the detoxification of xeno- or endobiotics, where glutathione transferases (GTs, EC 2.5.1.18) catalyze the conjugation of glutathione to electrophilic compounds, which facilitates transport into the vacuole for metabolization (Labrou et al
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