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One hypothesis involves the close association of eNOS with arginine transporters like CAT-1 and L-arginine recycling enzymes such as argininosuccinate lyase (ASL) (Erez et al., 2011)
Thioredoxins are important for antioxidative response in Lb
Therefore, as shown in Figure S5 , for a given pKa of niclosamide of 6.87, the position of this curve, that delineates the amount of niclosamide in solution across the whole pH range, is determined by the value for NIC OH , the low solubility acid, which, again, is measured here to be 1.77uM
It is unclear if our 2 patients who did not have AKI recovery would have eventually recovered if they lived or if they received a full weight-based rescue dose of glucarpidase
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