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The model was first fitted to the training concentrations (37.5 and 25 M doxorubicin), and then used to simulate the test concentrations (50, 12.5 and 10 M doxorubicin) as a means of blind validation, showing good accordance between the experimental and in silico outputs for all concentrations of doxorubicin

More research is needed to study the role of Prdx2 in jaundiced G6PD-deficient infants with and without acute hemolysis

Antioxidants also indirectly reduce oxidative damage by preventing the expression of enzymes responsible for generating ROS, such as NAD(P)H oxidase and xanthine oxidase, or by promoting the activity or expression of free radical scavengers

This could prevent ferroptosis and lessen inflammation caused by the release of lipid metabolites and damage-associated molecular patterns (Figure 2)

Accessed 2/16/2021, Park MK, Lee DY, Kim YH