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Wang et al., 2014)

JainABuistNRKennawayNGPowellBRAuldPAMrtenssonJ

As a result, altered intracellular glutathione homeostasis has been widely used as an indicator of oxidative stress

147,148 In one placebo-controlled trial in 46 men with low sperm numbers, those who received ashwagandha root extract (standardized to contain at least 5% withanolides), at 225 mg three times daily for 90 days, had a 167% increase in sperm number, 57% increase in sperm motility, and 53% increase in semen volume, while those who received placebo had little change in these parameters

In healthy humans, GIP-mediated elevation of circulating glucagon concentrations has also been observed