Additionally, the bioavailability of AS-IV in oral formulations remains a challenge, as the compound is poorly absorbed, which hinders its therapeutic potential in humans
These risk factors also appear to contribute to increased oxidative stress, leading to increased COVID-19 severity and mortality [4850]
Effect of daily intake of green tea catechins on cognitive function in middle-aged and older subjects: a randomized, placebo-controlled study
4.1 Indirect evidence One of the most promising indirect mechanisms is through the gut microbiota (41), which has been implicated in sleep regulation via the gutbrain axis (42, 43)
Authors contributions AR, FK, EZ, HS, and SM contributed to the conception and design, as well as the acquisition, analysis, and interpretation of data