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A clinical trial of canakinumab highlighted these hazards, reporting a 67 % infection rate over two years compared with 25 % in the placebo group 64

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66 In summary, continued discovery of novel AKT substrates involved in GLUT4 translocation indicates that many but not all of the same effectors are involved in the glucose uptake of different tissues, and further studies should be conducted to identify the molecular mediators in all phases of insulin-stimulated glucose uptake