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It is clear that comparative in vivo metabolism and toxicity studies need to be undertaken with AMAP in species other than hamster and mouse, most notably in the rat

We are awaiting publication.) As for a drug that might be more effective at reducing lactate, we did conduct a clinical trial of precisely such a drug dichloroacetate or DCA in patients with the syndrome of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS), a primary mitochondrial disorder with gallons of ventricular lactate

doi: 10.1186/s13073-022-01102-1

When peroxisomal catalase activity is compromised, excess HO diffuses into mitochondria, disrupting their dynamics and exacerbating oxidative stress