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Collectively, the Akt/mTOR/HIF-1 axis coordinates metabolic and epigenetic reprogramming to drive and maintain trained immunity, representing a potential target for therapeutic intervention

doi: 10.1016/j.molmet.2016.04.007 25 SamolsEMarriGMarksV

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This targeted approach aims to lighten pigmentation and even out skin tone, offering a promising solution for those seeking to reduce the appearance of melasma