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In addition to its role as a critical blood buffer, phosphate is required in the biosynthesis of cellular components, such as ATP, nucleic acids, phospholipids, and proteins, and is involved in many metabolic pathways, including energy transfer, protein activation, and carbon and amino acid metabolic processes

The intrinsic factors include neurotrophic factors [7], transcriptional programs [8], inflammatory cytokines [9], neurotransmitters and hormones [10]

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Often, the formulas are even customized