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Collectively, these studies suggest that xCT is beneficial for cancer cells by suppressing ferroptosis, while glucose deprivation and NADPH depletion caused by a reduction in carbon from glucose entering the PPP can promote cancer cell death [26,48]

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The depletion of GPX4 and GSH, the increased level of lipid peroxidation, and disrupted iron metabolism are vital features of ferroptosis (Egolf et al., 2021)

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