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Liver cirrhosis is associated with several abnormalities in the innate and adaptive components of the immune systems response to microbial challenge, leading to an acquired immunodeficiency state

The authors also stated that it was not known whether the abnormalities detected were of clinical importance

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In the context of AD, the inflammatory responses of M1 microglia, which are predominantly localized around the amyloid plaques, are initiated and sustained by P47 phagocyte oxidase and NF-B (nuclear factor kappa B) (130)

Activation of the transcription factor NF-kappaB in Schwann cells is required for peripheral myelin formation