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Key Functions of DSIP: Regulation of the Sleep-Wake Cycle Stress Reduction Pain Relief Support for the Opioid System : DSIP interacts with the brains opioid system, contributing to pain relief and stress reduction

A distinct tissue-repair cluster shared this profile but also upregulated genes involved in the remodeling of extracellular matrix ( Fbln2 , Col6a2 , Adamts1 , Adamts5 (Loreti and Sacco, 2022