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doi:10.1016/0006-2952(87)90132-8

Muscle Mass and Body Composition Research in growth hormone-deficient and intact animal models showed effects on lean body mass: 15.3% increase in body weight in GH-deficient mice treated with ipamorelin over 9 weeks Enhanced protein synthesis and nitrogen retention in skeletal muscle tissue Dose-dependent effects on body weight gain and lean mass accretion Preserved muscle mass during catabolic conditions in experimental models Studies using DEXA scanning confirmed increases in lean tissue mass with corresponding reductions in fat mass percentage

Therefore, IGF-1 deprivation seriously contributes to the progressive malnutrition of cirrhotic patients, increasing the vulnerability of the liver to an inflammatory and oxidative microenvironment with mitochondrial dysfunction

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