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In addition, the presence of multiple comorbidities increases the likelihood of drug-drug interactions and limits the patients physiologic reserve, rendering them more susceptible to cumulative toxicity, fatigue, and myelosuppression

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Patients with type 2 diabetes require individualized counseling about hypoglycemia risk, especially if taking additional glucose-lowering medications such as insulin or sulfonylureas

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Your optimal timing depends on individual metabolism and how quickly you typically fall asleep