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In addition, two groups of mice maintained on the VD-deficient HFD were also simultaneously supplemented by oral gavage with either water or the same dose of the vehicle used for dissolving cholecalciferol (OO) (Fig

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GI events (nausea, vomiting, diarrhea) were the dominant safety signal and occurred at rates higher than reported for Phase 2 retatrutide and higher than for comparable dual or mono-agonist trials