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139 RNA methylation RNA methylation, such as N 6 -methyladenosine (m 6 A), N 1 -methyladenosine (m 1 A), and 5-methylcytosine (m 5 C), has been revealed to be regulated by lactylation, involving histone Kla-induced expression of methylation-related enzymes and the direct lactylation of these proteins (Fig

Unlike typical cellular proteins, MOTS-c is encoded in the mitochondrial genome but translated in the cell cytoplasm, highlighting the unique cross-talk between mitochondria and the rest of the cell

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This approach revealed that the metabolic compensatory pathways that enable cells to overcome glutamine depletion are contingent on the capacity to synthesize glutamine via glutamine synthetase

PMID 19098042