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CheraghiMAhmadvandHMalekiABabaeenezhadEShakibaSHassanzadehF.Oxidative stress status and liver markers in coronary heart disease

2018;2:e00034

PLoS ONE 10 , e0123781 (2015)

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In this review, we emphasize on (1) GSH depletion as a fundamental risk factor for diseases like chronic obstructive pulmonary disease and atherosclerosis (ischemic heart disease and stroke), (2) importance of oxidative stress and antioxidants in SARS-CoV-2 infection and COVID-19 disease, (3) significance of GSH to counteract persistent damaging inflammation, inflammaging and early (premature) inflammaging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses in younger individuals, and (4) new therapies that include antioxidant defenses restoration