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Therefore, in-depth analysis of the exact regulatory network of Bacteroidetes in the pathogenesis of OA through the gut-joint axis, and clarification of the functional specificity of different Bacteroides strains and their interactions with host metabolism, immune and inflammatory pathways, are of great theoretical and clinical significance for accurately understanding the mechanism of the influence of gut microbiota on OA and developing probiotic intervention strategies targeting specific strains

Ultimately, 14 RCTs 10,11,1526 and one open-label clinical trial 12 met the inclusion criteria

Patients with secondary carnitine deficiency accumulate organic acids which causes enhanced urinary excretion of carnitine in the form of acyl-carnitines [36, 37]

Homocysteine levels and the risk of osteoporotic fracture

Direct injection into already damaged tissue causes additional trauma and may worsen the condition