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For aesthetic applications, TB-500s main use is in improving scar appearance, accelerating healing after procedures, and supporting the collagen remodeling phase that determines whether a healed wound leaves smooth or irregular scar tissue

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Further development of TGR-based therapeutic approaches is impeded by the lack of non-covalent small molecule inhibitors of TGR, a well-known and general problem for all the members of the high molecular weight, Sec-containing TrxR subfamily that are considered attractive and unexploited drug targets for several human diseases 21,22

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Vitamin C inactivates the proteasome inhibitor PS-341 in human cancer cells