Interestingly, we noted that expression levels of serine/glycine synthesis enzymes are elevated by at least 4-fold in 80% of all T-cell leukaemias, whereas the RPL10 R98S mutation is only present in 8% of the samples, suggesting that other factors may be driving serine/glycine synthesis addiction in this type of cancer
Heithoff BP, George KK, Phares AN, Zuidhoek IA, Munoz-Ballester C, Robel S
Regional specificity of aberrant thalamocortical connectivity in autism
mTOR mediates the localization of mitochondria towards the plasma membrane, eventually partaking in prolonged contact
These biochemical adaptations result in a metabolic reprogramming that promotes lactate production and accumulation, thereby reinforcing the hypoxic cellular response