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Metformin induces vitamin B12 malabsorption, which may increase the risk of developing vitamin B12 deficiency, a clinically important and treatable condition

The medication does not directly increase metabolic rate or preferentially promote fat burning

NIH ODS Fact Sheet for Health Professionals: Vitamin B12 (updated 2024)

The short answer is yes but only if you're low

By delivering the vitamin directly into the bloodstream, injections provide a reliable and effective way to restore levels when tablets are not sufficient. How Vitamin B12 Deficiency Develops Over Time How Vitamin B12 Deficiency Develops Over Time Vitamin B12 deficiency does not usually appear suddenly