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In addition to inhibition of hydroperoxide-dependent reactions, GPX4 has the additional function of inhibiting the activity of the ALOX (arachidonate lipoxygenase) family [52]

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Aberrant vasculature resulting from tumor angiogenesis plays a critical role in the development of resistance to breast cancer treatments, via exacerbation of tumor hypoxia, decreased effective drug concentrations within tumors, and immune-related mechanisms