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FIGURE 2 3.2 Nitazoxanide lessened oxidative stress in rats with MTX-hepatotoxicity As an indicator for lipid peroxidation, hepatic MDA was determined, and a significant rise in hepatic MDA was found in the MTX group as compared to CTRL

330 Another PRMT5 inhibitor, JNJ-64619178, has shown long-term PRMT5 inhibition and potent anti-tumor effect in lung, pancreatic, and hematological tumors