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5.1 Immune-inflammatory pathways As the largest immune organ in the human body, the gut harbors 70% of immune cells and coordinates immune function through microbial metabolites such as SCAFs, thereby regulating neuroinflammatory responses (Mann et al., 2024)

Abatacept treatment significantly reduced the proportions of Tregs and PD-1 + TFh cells and is effective in clinical patients with RA (Huang et al., 2021a)

Monocytes and macrophages are also influenced by GSH levels

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Beneficial effects of a high-protein, low-glycemic-load hypocaloric diet in overweight and obese women with polycystic ovary syndrome: a randomized controlled intervention study