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145 The roles of PGC-1s in biological functions and physiological processes The effect of PGC-1s in mitochondrial functions Mitochondria, serving as organelles responsible for energy generation in OXPHOS, are crucial for the activity, function, and viability of eukaryotic cells

However, at excessive levels, ROS exert toxic effects and directly oxidize biological macromolecules, such as proteins, nucleic acids and lipids, further exacerbating the development of inflammatory responses and causing various inflammatory diseases

Biochemistry 55(48):66736684 Yang WS et al (2016) Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

The use of inhibitors of glutamine metabolism alone, while enhancing antitumor immunity, has some limitations