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The consistency of the safety profile across short-term and long-term trials suggests that AOD-9604 does not produce cumulative toxicity or delayed adverse effects that emerge only with chronic administration

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Moreover, it reveals that possible mechanisms behind this effect might include granulation tissue formation, reepithelialization and deposition of collagen through the ERK1/2 signaling pathway [6] 3

The cream is not meant for long-term usage as it may become harsh on the skin and causes rashes in the applied areas