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1h (ii)), shown at higher magnification in Supplementary Fig

Among antioxidants whose presence has been documented in the thyroid, peroxiredoxins (Prxs) are of a special significance, as they are involved in the process of H 2 O 2 elimination, when this ROS is formed in response to TSH, and they protect thyroid cells from H 2 O 2 -induced apoptosis [130, 131]

This opened new clinical applications for NADs in treating human diseases

However, control of the mechanism of GSH synthesis in malignant tumors remains poorly understood

The evidence consists of mechanistic research on each compound individually, small observational studies from anti-aging clinics, and patient-reported outcomes from practitioners using the protocol off-label