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Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice
Cardiomyocytes, on the other hand, are primarily responsible for the contractile function of the heart, and mitophagy in cardiomyocytes is mainly used to maintain the highly demanded energy production and to ensure the effectiveness of the hearts pumping functions [59]
One-way ANOVA followed by Dunnetts multiple comparisons test was performed using GraphPad Prism version 8.0.0 for Windows (GraphPad Software, San Diego, California USA, www.graphpad.com)
In this population: Higher waist-to-hip ratio increased risk up to 7.7-fold (especially peri-menopausally) Greater body fat percentage, waist-height ratio, or visceral fat area each increased risk around 4-fold Higher body mass index (BMI) or waist circumference, each, increased risk almost 3-fold Because obesity is associated with significant changes in immunometabolic and hormonal parameters, it seems likely that the strength of these findings will be confirmed in other populations
FAD, Familial Alzheimers disease
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