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Protein deficiency in SAM disrupts many pathways in energy metabolism including the Tricarboxylic Acid Cycle, the Electron Transport Chain, and -oxidation and perturbs gut microbiota, iron and amino acid metabolism [135, 136]

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Res 3 , 9498 (2015)

The first sub-analysis involved stratifying patients based on their AHM initiation status: newly-initiated users (patients who started AHMs on or after January 1, 2011, with no prior recorded use) and prevalent users (patients with a history of AHM use before January 1, 2011)