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Canada: Wiley Publications

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At the same time, desmosterol, the immediate precursor of cholesterol in the Bloch biosynthetic pathway, together with oxysterols, binds to and activates LXRs, leading to up-regulation of genes involved in cholesterol efflux, such as ATP-binding cassette sub-family A member 1 (ABCA1), ATP-binding cassette sub-family G member 1 (ABCG1), ATP-binding cassette sub-family G member 5 (ABCG5) and ATP-binding cassette sub-family G member 8 (ABCG8), and others such as myosin regulatory light chain interacting protein (MYLIP)

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