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During the initial phase of cytomegalovirus infection, viral DNA is introduced into the nuclei of uninfected retinal cells, instigating viral DNA transcription and the production of viral particles, thereby initiating an immune response [142, 143]

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In addition, loss of podocytes, either due to apoptosis and/or podocyte detachment from the glomerular basement membrane, was shown to be an early event in the development of diabetic nephropathy in humans and various animal models of diabetic nephropathy [196,197,198]

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