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However, in 2001, a handful of groundbreaking research discoveries confirmed that the Ca 2+ ionophore ionomycin could trigger an apoptosis-like cell death in erythrocytes associated with the appearance of apoptotic signs, including cell shrinkage, membrane vesiculation, or PS exposure [22, 23]

Research by Berlanga-Acosta et al

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This inconsistency can complicate literature reviews and meta-analyses

These systems enhance bioavailability through multiple mechanisms: particle size reduction increases surface area-to-volume ratios, amorphous state formation prevents crystallization, and surface modification improves wettability