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e071725e071725, www.bmj.com/content/383/bmj-2022-071725, Dangour, Alan D, et al

The abnormal extracellular matrix and tumor vasculature surrounding tumor cells result in uneven drug distribution within the tumor, thereby reducing the effective drug concentration ( CAFs play a critical role in tumor progression and drug resistance by secreting growth factors and cytokines that promote tumor cell proliferation and migration

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Lockhart et al., 2023)

They control mast cell differentiation, proliferation, function, and resolution of immune responses.[ref] MiRNAs have been shown to be upregulated in mast cell activation, and miRNAs can also suppress degranulation or cytokine release