the AngIV Analog D-Nle-Tyr-Ile-NH(CH 2 ) 5 CONH 2 is More Metabolically Stable than Norleual (Nle-Tyr-Leu- -(CH 2 NH 2 ) 3-4 -His-Pro-Phe (SEQ ID NO: 1): AngIV-related peptidomimetic Norleual was previously shown to possess, anti-HGF/Met, anti-angiogenic, and anti-cancer activities (Yamamoto et al., 2010)
Hippocampal neurons transfected with mRFP-P-actin were treated with vehicle (PBS), 10 -12 M Nlel-AnglV, as a positive control, or various concentrations for several stabilized analogs for 5 days in culture or for 30 minutes prior to fixation on day in vitro 12 (DVI12)
Then, the developed LS nanospanlastics dispersions were stored for 24 h at 4 C in the refrigerator for further measurements
Phospholipid peroxidation leads to dopaminergic neuron loss in synucleinopathies
J Physiol Paris 95:283288 Sikiric P, Jelovac N, Jelovac-Gjeldum A et al (2002) Pentadecapeptide BPC 157 attenuates chronic amphetamine-induced behavior disturbances