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Redox mechanisms of cytoprotection by Bcl-2

Genomic instability induced by ROS is generally regarded as the main mutagenic force of tumor initiation, such as the mutation of the oncogene RAS and the tumor suppressor gene TP53

[DOI] [PMC free article] [PubMed] [Google Scholar] 236.Treves H., Siemiatkowska B., Luzarowska U., Murik O., Fernandez-Pozo N., Moraes T.A., Erban A., Armbruster U., Brotman Y., Kopka J., et al

It is naturally present in every cell of the human body, where it performs a number of essential functions: Supports detoxification processes Protects cells from oxidative stress Participates in the regeneration of other antioxidants (e.g., vitamins C and E) Supports proper liver function and immune system activity Over time and due to stress, illness, poor diet, or exposure to toxins the bodys natural glutathione levels may decline

They are formed through a process called keratinization, aka epidermal cell differentiation