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However, understanding the theoretical framework helps professionals make informed decisions: Tirzepatide mechanism: Dual GIP/GLP-1 receptor agonist Already combines two incretin pathways Produces substantial weight loss (15-20% in clinical trials) Potential cagrilintide addition: Would add amylin pathway activation Could theoretically enhance gastric emptying delay Might increase satiety beyond tirzepatide alone Important consideration : Combining multiple appetite-suppressing peptides significantly increases the risk of gastrointestinal side effects

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DOI: 10.1093/ajcn/nqy376