Adrenal-derived 11-oxygenated 19-carbon steroids are the dominant androgens in classic 21-hydroxylase deficiency
Is the outcome a hormone surrogate (GH, IGF-1) or a clinical/imaging endpoint (visceral fat, liver fat)
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Under pro-inflammatory conditions, as evidenced by interventions with LPS or IFN-, microglia are insensitive to ferroptosis, yet susceptible to iron overload ( in vitro data showed that genetic depletion of iNOS renders Raw264.7 cells and EOC 20 cells vulnerable to ferroptosis, whereas NO donors (SNAP, DPTA-NONOate) empower the ferroptotic resistance of M2 microglia ( The sophisticated interplay between neuroinflammation, instigated by microglia in response to inflammatory stimuli, and ferroptosis in microglia has been documented
