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Patients were excluded if they took non-steroidal anti-inflammatory drugs (NSAIDs), any change in the dose, type, or frequency of DMARDs, consumed alcohol, had other autoimmune diseases, kidney disorders, pancreatitis, gallstones, or cancer, followed special diets in the past three months, or had recent medication changes

This small molecule, dihexa, penetrates the BBB, induces spinogenesis/synaptogenesis at picomolar concentrations [70] , and is slowly cleared from the blood (plasma stability t 1/2 = 335.5 min) [73]

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Proc Am Assoc Cancer Res 41:731, 2000

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