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Lee B-J, Tseng Y-F, Yen C-H, Lin P-T
Decreased NAD + levels can contribute to sirtuin mediated deacetylase-dependent alterations in both mitochondrial electron transport activity (resulting in increased production of reactive oxygen species, ROS) as well as to increased nuclear DNA damage leading to the activation poly-ADP-ribose polymerases (PARP)
10.1016/s0006-8993(99)02122-8 Brain Res
As CBS is involved in the transsulfuration pathway for the generation of cysteine, the activity of this enzyme can affect the degree of antioxidant capacities of cells
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