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However, the glucuronidation pathway is not upregulated by repeated exposure to APAP [71] and is a minor pathway in babies and children, as discussed above [63,64]

Gotardo, E

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Targeting neuroinflammatory pathways therefore represents a critical therapeutic avenue for the development of novel and adjunctive antidepressant strategies (32, 34)

Some convincing evidence from genetic deletion animal models further supports the critical roles of PGC-1 in HF