Although homocysteine is naturally occurring in the human body, in cases where methylation is impaired it accumulates and may cause disease.[26] Raised levels of homocysteine have been associated with an increased risk for many disorders, including vascular and neurodegenerative diseases, autoimmune disorders, birth defects, diabetes, renal disease, osteoporosis, neuropsychiatric disorders, chronic fatigue, and cancer.[27],[28],[29] Interestingly, a large body of data links hyperhomocysteinaemia and folate status with oxidant stress
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