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88 -ketoglutaric acid (-KG) is a key metabolic intermediate in the mitochondrial tricarboxylic acid (TCA) cycle

Engages FOXO transcription factor signaling networks: FOXO transcription factors regulate oxidative stress resistance, metabolic adaptation, and longevity-associated gene expression

HFpEF exhibits more complexity and has more associated-comorbidities including hypertension compared to HFrEF, and systemic inflammation and its-induced metabolic injury are closely associated with the pathogenesis of HFpEF

Almanza-Monterrubio M, Garnica-Hayashi L, Dvila-Camargo A, Nava-Castaeda

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