Nature Reviews Molecular Cell Biology (2021) 10
combined single-cell RNA sequencing and population-level genetic analyses to reveal two key chondrocyte subpopulations, inflammatory and fibrocartilage chondrocytes, that are expanded in hand OA and enriched for ferroptosis-related and inflammatory pathways, with elevated expression of FTH1, implicating iron overload in OA pathogenesis ( + T cells in the synovium as drivers of cartilage degeneration and subchondral bone damage through interactions with chondrocytes, offering mechanistic insight into immune-mediated OA progression (Sun et al., 2024)
The oxidative stress declines, neurotransmitters stabilize, and emotional regulation improves
TB-500 is a synthetic analog of thymosin beta-4 (TB4) , a protein found in most human and animal cells
Increased cystine uptake, via the increased expression of the SCL7A11 transporter, has been shown to contribute to changes in the epigenome